RESCUE‐ICAS: Rationale and Study Design

Background Mechanical thrombectomy (MT) failure occurs in ≈10% to 20% of MTs. Among the common causes failed MT is residual underlying intracranial stenosis (ICAS), typically attributable atherosclerotic disease. ICAS large‐vessel occlusion (ICAS‐LVO) remains poorly understood, and management ICAS‐LVO unclear. The RESCUE‐ICAS (Registry Emergent Large Vessel Occlusion Due Intracranial Stenosis) aims at providing better understanding prevalence ICAS‐LVO, overall safety efficacy various rescue therapies. Methods a multicenter, international, prospective registry that currently enrolling patients with who underwent MT. All sites are required report monthly cases meet inclusion criteria. decision whether use therapy up interventionist. Results We will collect patients’ demographic, clinical, radiographic data baseline. Also, we capture variables related procedure (if performed), postprocedural clinical imaging variables. Outcomes include rate successful recanalization, defined by modified Thrombolysis Cerebral Infarction score ≥2b, symptomatic hemorrhage, 90‐day Rankin scale score, mortality. Conclusions No strong evidence available support an optimal treatment strategy for undergoing cohort study provide important help design randomized controlled trials.